Math Lady / Confused Lady refers to pictures or gifs of Brazilian actress Renata Sorrah playing Nazaré Tedesco in a scene from the telenovela, Senhora do Destino. And yes, is not Julia Roberts as everyone has thought. Originally, this reaction hasn't include numbers, but after the math symbols were added, the image and gif surged in popularity, particularly on Brazilian parts of social media, before it grew popular worldwide. Now you can use it whenever you are not getting what people is saying in the meeting or whenever.